Hypercoordinated Carbon in 2,8,9-Sila- and Thia-Substituted Carbatranes

Clathrate inclusion behaviour of thia - substituted diquinoline host molecules

Continuing our search for new compounds which function as lattice inclusion hosts, the thia-substituted diquinoline derivatives 5 and 6 have been synthesised and the X-ray structures of (5)6?(CH3OH) and (6)?(benzene) determined. A literature survey on the thioether–1,3-peri aromatic hydrogen interaction reveals that this is reasonably common, but neither crystal structure contains this motif de...

In vitro metabolism of haloperidol and sila-haloperidol: new metabolic pathways resulting from carbon/silicon exchange.

The neurotoxic side effects observed for the neuroleptic agent haloperidol have been associated with its pyridinium metabolite. In a previous study, a silicon analog of haloperidol (sila-haloperidol) was synthesized, which contains a silicon atom instead of the carbon atom in the 4-position of the piperidine ring. In the present study, the phase I metabolism of sila-haloperidol and haloperidol ...

Ddh249 289..296

Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun to tie together some of the known pathways. Muta...

Bez nazwy-289

Pns1300387 289..301

Epidemiological studies, including those in identical twins, and in individuals in utero during periods of famine have provided robust evidence of strong correlations between low birthweight and subsequent risk of disease in later life, including type 2 diabetes (T2D), CVD, and metabolic syndrome. These and studies in animal models have suggested that the early environment, especially early nut...